The Pfam protein families database

Finn Robert D<sup>*</sup>; Tate John; Mistry Jaina; Coggill Penny C; Sammut Stephen John; Hotz Hans Rudolf; Ceric Goran; Forslund Kristoffer; Eddy Sean R; Sonnhammer Erik L L; Bateman Alex

doi:10.1093/nar/gkm960

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The Pfam protein families database

作者：Finn Robert D^*; Tate John; Mistry Jaina; Coggill Penny C; Sammut Stephen John; Hotz Hans Rudolf; Ceric Goran; Forslund Kristoffer; Eddy Sean R; Sonnhammer Erik L L; Bateman Alex

来源：Nucleic Acids Research, 2008, 36(Database): D281-D288.

DOI：10.1093/nar/gkm960

摘要

Pfam is a comprehensive collection of protein domains and families, represented as multiple sequence alignments and as profile hidden Markov models. The current release of Pfam ( 22.0) contains 9318 protein families. Pfam is now based not only on the UniProtKB sequence database, but also on NCBI GenPept and on sequences from selected metage-nomics projects. Pfam is available on the web from the consortium members using a new, consistent and improved website design in the UK (http://pfam.sanger.ac.uk/), the USA (http://pfam.janelia.org/) and Sweden (http://pfam.sbc.su.se/), as well as from mirror sites in France (http://pfam.jouy.inra.fr/) and South Korea (http://pfam.ccbb.re.kr/).