Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge

作者：Loyola Adriano Mota^*; Cardoso Sergio Vitorino; de Faria Paulo Rogerio; Silva Servato Joao Paulo; Amaral Eisenberg Ana Lucia; Dias Fernando Luiz; Thavaraj Selvam; Gomes Carolina Cavalieri; Gomez Ricardo Santiago

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2015, 120(3): 368-377.

DOI：10.1016/j.oooo.2015.05.011

Objective. To describe the clinicopathologic and immunohistochemical features of five cases of adenoid ameloblastoma.
Study Design. Clinicopathologic data were gathered from medical records and compared with those compiled from a systematic review. Slides were also immunohistochemically stained for Ki-67, p16, p53, and cytokeratins (7, 8, 14, 18, and 19).
Results. There were 3 males (60%) and 2 (40%) females. The mean age was 44 +/- 10 years. Of the five adenoid ameloblastomas, 4 (80%) occurred in the posterior maxilla. Patients typically complained of asymptomatic swelling. All patients received surgical resection as primary therapy; 1 (20%) patient also received adjuvant radiotherapy. Recurrence was diagnosed in all patients. Immunohistochemically, the tumors stained focally positive for CK7, 8, 14, and 18 and diffusely positive for CK-19, p16, and p53. The mean Ki-67epositive cells were 72.4 +/- 24.9 positive cells per high-power field (range 53-111).
Conclusions. To our knowledge, this is the largest series of adenoid ameloblastoma reported in the literature. Our data suggest that this entity demonstrates aggressive behavior characterized by a high likelihood of recurrence.

• 出版日期2015-9