Amazing structure of respirasome: unveiling the secrets of cell respiration

作者：Guo Runyu; Gu Jinke; Wu Meng; Yang Maojun^*

来源：Protein & Cell, 2016, 7(12): 854-865.

DOI：10.1007/s13238-016-0329-7

• respirasome structure
• supercomplexes organization
• cellular respiration
• respiratory complexes
• megacomplex

Respirasome, a huge molecular machine that carries out cellular respiration, has gained growing attention since its discovery, because respiration is the most indispensable biological process in almost all living creatures. The concept of respirasome has renewed our understanding of the respiratory chain organization, and most recently, the structure of respirasome solved by Yang's group from Tsinghua University (Gu et al. Nature 237(7622):639-643, 2016) firstly presented the detailed interactions within this huge molecular machine, and provided important information for drug design and screening. However, the study of cellular respiration went through a long history. Here, we briefly showed the detoured history of respiratory chain investigation, and then described the amazing structure of respirasome.

• 出版日期2016-12
• 单位清华大学