Association of lymphocyte-monocyte ratio and monocyte-to-high-density lipoprotein ratio with the presence and severity of rheumatic mitral valve stenosis

作者：Demir Vahit; Samet Yilmaz^*; Akboga Mehmet Kadri

来源：Biomarkers in Medicine, 2017, 11(8): 657-664.

DOI：10.2217/bmm-2017-0036

• echocardiography
• inflammation
• lymphocyte-to-monocyte ratio
• mitral stenosis
• monocyte-to-high-density lipoprotein ratio
• rheumatic mitral valve

Aim: We aimed to evaluate the relationships between monocyte-to-high-density lipoprotein ratio (MHR) and lymphocyte-to-monocyte ratio (LMR) and rheumatic mitral valve stenosis (RMVS). Methodology: A total of 368 patients with mitral stenosis and 80 healthy participants were included. Patients were categorized into two groups in respect to the severity of RMVS as mild-moderate group (mitral valve area >= 1.0 cm(2)) and severe group (mitral valve area < 1.0 cm(2)). Results: The MHR (10.6 +/- 2.3, 11.6 +/- 2.6, 13.8 +/- 3.1; p < 0.001) and C-reactive protein levels (control group, nonsevere RMVS and severe RMVS groups 3.4 +/- 0.7, 4.4 +/- 1.1, 5.2 +/- 1.4, respectively; p < 0.001) were significantly increased whereas LMR (4.51 +/- 1.3, 3.57 +/- 1.3, 3.14 +/- 1.4; p < 0.001) levels were significantly decreased in parallel to the severity of mitral stenosis. Discussion/conclusion: MHR and LMR can be used to predict severity of RMVS.

• 出版日期2017-8