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摘要
New diazabicyclo[2.2.2]octane derivatives, peniciherquamides A-C (1-3), and a novel herqueinone derivative, neoherqueinone (5), were isolated from a fungal culture broth of Penicillium herquei. The structures of these novel compounds were determined by interpretation of spectroscopic data (1D/2D NMR, MS, and IR). Four known compounds, preparaherquamide (4), peniciherqueinone (6), and herqueinone/isoherqueinone (7/7a), were also obtained. The isolated compounds were tested for anti hepatitis C virus (HCV) activity, and peniciherquamide C (3) was found to display an IC50 value of 5.1 mu M. To our knowledge, this is the first report of a diazabicyclo[2.2.2]octane derivative with anti-CV activity.
- 出版日期2016-2
