Blood pressure and TNF-alpha act synergistically to increase leucocyte CD11b adhesion molecule expression in the BELFAST study: implications for better blood pressure control in ageing

作者：Rea I Maeve^*; McNerlan Susan E; Alexander Denis H; Armstrong Michelle E

来源：Age, 2013, 35(1): 197-205.

DOI：10.1007/s11357-011-9326-1

• Blood pressure
• TNF-alpha
• Leucocyte adhesion
• CD11b/18
• Ageing
• BELFAST study

Hypertension, a key risk factor for stroke, cardiovascular disease and dementia, is associated with chronic vascular inflammation, and although poorly understood, putative mechanisms include pro-inflammatory responses induced by mechanical stretching, with cytokine release and associated up-regulated expression of adhesion molecules. Because blood pressure increases with age, we measured baseline and tumour necrosis alpha (TNF-alpha)-stimulated CD11b/CD18 adhesion molecule expression on leucocytes to assess any association between the two. In 38 subjects (mean age 85 years), consecutively enrolled from Belfast Elderly Longitudinal Free-Living Aging Study (BELFAST), baseline and TNF-alpha-stimulated CD11b/CD18 expression on separated monocytes and neutrophils increased with systolic blood pressure %26gt; 120 mmHg (p = 0.05) and for lymphocytes, with diastolic blood pressure %26gt; 80 mmHg (p %26lt; 0.05).These findings show increased potential stickiness of intravascular cells with increasing blood pressure which is accentuated by TNF-alpha, and suggest mechanistic reasons why better hypertension control is important.

• 出版日期2013-2