A new motif in the formation of peptide nanotubes: The crystallographic signature

作者：Ray S^*; Haldar D; Drew MGB; Banerjee A

来源：Organic Letters, 2004, 6(24): 4463-4465.

DOI：10.1021/ol048253a

Terminally protected acyclic tripeptides Boc-Tyr(1)-Val(2)-Tyr(3)-OMe 1 and Boc-Tyr(1)-lle(2)-Tyr(3)-OMe 2 self-assemble into nanotubes in crystals through various noncovalent interactions with an average internal diameter of 5 Angstrom (0.5 nm), and the tubular ensemble is developed through the hydrogen-bonded side chains of tyrosine residues. The inside of the hollow nanotubular structures is hydrophilic; however, no solvent molecules have been crystallographically detected.

• 出版日期2004-11-25