An MRI-Based Semiquantitative Index for the Evaluation of Brain Atrophy and Lesions in Alzheimer's Disease, Mild Cognitive Impairment and Normal Aging

作者：Chen, Wei; Song, Xiaowei^*; Zhang, Yunting; Darvesh, Sultan; Zhang, Ningnannan; D'Arcy, Ryan C. N.; Black, Sandra; Rockwood, Kenneth

来源：Dementia and Geriatric Cognitive Disorders, 2010, 30(2): 121-130.

DOI：10.1159/000319537

• Aging
• Alzheimer's disease
• Brain lesions
• Brain atrophy
• Mild cognitive impairment

Background: This study investigates how T-1-weighted MRI can be used to evaluate brain anatomical changes. We investigated these changes in Alzheimer's disease (AD) and normal aging. Methods: A semiquantitative brain atrophy and lesion index (BALI) was constructed by adapting existing visual rating scales and validated in 3 datasets. Results: The T-1- and T-2-weighted-imaging-based scores were highly correlated. They were both closely associated with age and with cognitive test scores. Conclusion: The T-1-based BALI helps describe brain structural variability in AD, mild cognitive impairment and normal aging.

• 出版日期2010
• 单位天津医科大学