Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

作者：Hirano Harutoyo; Takama Renjo; Matsumoto Ryo; Tanaka Hiroshi; Hirano Hiroki; Soh Zu; Ukawa Teiji; Takayanagi Tsuneo; Morimoto Haruka; Nakamura Ryuji; Saeki Noboru; Hashimoto Haruki; Matsui Shogo; Kishimoto Shinji; Oda Nozomu; Kajikawa Masato; Maruhashi Tatsuya; Kawamoto Masashi; Yoshizumi Masao; Higashi Yukihito^*; Tsuji Toshio^*

来源：Scientific Reports, 2018, 8(1): 9263.

DOI：10.1038/s41598-018-27392-3

This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flowmediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mm Hg higher than the subject's lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMD(L), for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMD(L) were 30.5 +/- 12.0% for the healthy subjects, 23.6 +/- 12.7% for subjects at high risk of arteriosclerosis and 14.5 +/- 15.4% for patients with CAD. The %ezFMD(L) values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.

• 出版日期2018-6-18