A highly efficient Pd-C catalytic hydrogenation of pyridine nucleus under mild conditions

作者：Cheng Chuanjie; Xu Jimin; Zhu Rui; Xing Lixin; Wang Xinyan^*; Hu Yuefei

来源：Tetrahedron, 2009, 65(41): 8538-8541.

DOI：10.1016/j.tet.2009.08.011

• Palladium
• Hydrogenation
• Pyridine nucleus
• Pyridinecarboxamides
• Piperidinecarboxamide

A synergistic Pd-C catalytic hydrogenation of 4-pyridinecarboxamides straightforward to 4-piperidinecarboxamide hydrochlorides was developed in the presence of ClCH(2)CHCl(2). It provided a novel strategy for highly efficient hydrogenation of pyridine nuclear by using low-cost Pd-C catalyst under mild conditions.

• 出版日期2009-10-10
• 单位清华大学