A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses

作者：Hoelscher Mary A; Singh Neetu; Garg Sanjay; Jayashankar Lakshmi; Veguilla Vic; Pandey Aseem; Matsuoka Yumi; Katz Jacqueline M; Donis Ruben; Mittal Suresh K; Sambhara Suryaprakash^*

来源：Journal of Infectious Diseases, 2008, 197(8): 1185-1188.

DOI：10.1086/529522

Development of effective and immunogenic vaccines against highly pathogenic avian influenza H5N1 viruses with the potential to cause a pandemic is a public health priority. The global demand for a vaccine cannot be met in the event of an influenza pandemic because of the limited capacity to manufacture egg-derived vaccines as well as potential problems with the availability of embryonated eggs. Thus, there is an urgent need to develop alternative, egg-independent vaccines. We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses.

• 出版日期2008-4-15