High-affinity IgA needs T(H)17 cell functional plasticity

作者:Milpied Pierre J*; McHeyzer Williams Michael G
来源:Nature Immunology, 2013, 14(4): 313-315.

摘要

The conversion of cells of the T(H)17 subset of helper T cells that previously expressed interleukin 17A (IL-17A) and the transcription factor ROR gamma t into follicular helper T cells is needed to generate antigen-specific immunoglobulin A in gut mucosa, which suggests new connections in the cognate control of regional adaptive immunity.

  • 出版日期2013-4