Tomographic molecular imaging of x-ray-excitable nanoparticles

作者：Pratx Guillem; Carpenter Colin M; Sun Conroy; Rao Ravi P; Xing Lei^*

来源：Optics Letters, 2010, 35(20): 3345-3347.

DOI：10.1364/ol.35.003345

X-ray luminescence computed tomography (XLCT) is proposed as a new dual molecular/anatomical imaging modality. XLCT is based on the selective excitation and optical detection of x-ray-excitable nanoparticles. As a proof of concept, we built a prototype XLCT system and imaged near-IR-emitting Gd(2)O(2)S:Eu phosphors in various phantoms. Imaging in an optically diffusive medium shows that imaging performance is not affected by optical scatter; furthermore, the linear response of the reconstructed images suggests that XLCT is capable of quantitative imaging.

• 出版日期2010-10-15