Nitric oxide, a protective molecule in the cardiovascular system

作者：Lei Jing^*; Vodovotz Yoram; Tzeng Edith; Billiar Timothy R

来源：Nitric Oxide-Biology and Chemistry, 2013, 35: 175-185.

DOI：10.1016/j.niox.2013.09.004

• Nitric oxide
• Endothelial cell
• Smooth muscle cell
• Blood vessel injury
• Intimal hyperplasia
• Transplant vasculopathy

Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell. and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.

• 出版日期2013-11-30