Muscle Extracellular Matrix Scaffold Is a Multipotent Environment

作者:Aulino Paola; Costa Alessandra; Chiaravalloti Ernesto; Perniconi Barbara; Adamo Sergio; Coletti Dario; Marrelli Massimo; Tatullo Marco*; Teodori Laura
来源:International Journal of Medical Sciences, 2015, 12(4): 336-340.
DOI:10.7150/ijms.10761

摘要

The multipotency of scaffolds is a new concept. Skeletal muscle acellular scaffolds (MAS) implanted at the interface of Tibialis Anterior/tibial bone and masseter muscle/mandible bone in a murine model were colonized by muscle cells near the host muscle and by bone-cartilaginous tissues near the host bone, thus highlighting the importance of the environment in directing cell homing and differentiation. These results unveil the multipotency of MAS and point to the potential of this new technique as a valuable tool in musculo-skeletal tissue regeneration.

  • 出版日期2015