An Efficient and Convenient Approach for the Synthesis of Novel Pyrazolo[1,2-a]triazole-triones and Evaluation of their Antimicrobial Activities

作者：Saluja Pooja; Khurana Jitender M^*; Sharma Chetan; Aneja Kamal R

来源：Australian Journal of Chemistry, 2014, 67(6): 867-874.

DOI：10.1071/CH13586

A new protocol for the efficient synthesis of novel pyrazolo[1,2-a]triazole-1,3,5-triones has been developed. The synthesis was achieved by reaction of aromatic aldehydes, Meldrum's acid, and 4-phenylurazole in the presence of a catalytic amount of glacial AcOH at 80 degrees C. The structural assignment has been unambiguously confirmed by X-ray analysis. The present finding provides an environmentally benign, efficient, and promising synthetic strategy for the synthesis of libraries with diversity. These compounds were tested in vitro for their antibacterial activity against four strains, namely Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa and antifungal activity against two fungal strains, namely Aspergillus niger and Aspergillus flavus.

• 出版日期2014