Application of Malononitrile in Multicomponent Reactions

作者：Wang Qifang^*; Song Xiaokai; Yan Chaoguo

来源：Progress in Chemistry, 2009, 21(5): 997-1007.

• multicomponent reactions
• malononitrile
• Knoevenagel condensation
• Michael addition
• cyclization
• elimination

Malononitrile is a particularly versatile compound, since the strongly electron-withdrawing cyano groups activate the methylene group, the polar multiple bond is suitable for nucleophilic addition and is also a good leaving group for substitution. The methylene group and one or both cyano groups can take part In condensation reactions to give a variety of addition products and heterocyclic compounds. This unique reactivity makes malononitnile an important candidate for multicomponent reactions. There have been a lot of multicomponent reactions with malononitrile for preparing carbocyclic and heterocyclic compounds. We review potential applications of malononitrile in multicomponent reactions, especially the recent representative examples for preparing heterocyclic compounds. The perspective for future development in this field is also briefly discussed.

• 出版日期2009-5
• 单位扬州大学