A model for coupling within-host and between-host dynamics in an infectious disease

作者：Feng Zhilan; Velasco Hernandez Jorge^*; Tapia Santos Brenda; Leite Maria Conceicao A

来源：Nonlinear Dynamics, 2012, 68(3): 401-411.

DOI：10.1007/s11071-011-0291-0

• Disease persistence
• Early viremia
• Multistability
• Multiparameter bifurcation

Studies on the modeling of the coupled dynamics of infectious diseases at both the population level (the epidemic process or between-host dynamics) and at the cell level (the early viremia or within-host dynamics) are scarce. Most of them deal with these two processes separately by postulating assumptions that render them decoupled. %26lt;br%26gt;In this work, we present a new model that allows the two dynamic processes to explicitly depend on each other. It is shown that new properties can emerge from the coupled system and more complex dynamics may be expected.

• 出版日期2012-5