Association of IL-8 With Infarct Size and Clinical Outcomes in Patients With STEMI

作者：Shetelig Christian^*; Limalanathan Shanmuganathan; Hoffmann Pavel; Seljeflot Ingebjorg; Gran Jon M; Eritsland Jan; Andersen Geir O

来源：Journal of the American College of Cardiology, 2018, 72(2): 187-198.

DOI：10.1016/j.jacc.2018.04.053

• acute myocardial infarction
• inflammation
• interleukin-8

BACKGROUND Little is known about the role of interleukin (IL)-8 in patients with acute ST-segment elevation myocardial infarction (STEMI).
OBJECTIVES The aims of this study were to evaluate, in STEMI patients, the temporal profile of IL-8 and possible associations with left ventricular (LV) function and remodeling, infarct size, microvascular obstruction, myocardial salvage, and future clinical events.
METHODS A total of 258 patients with STEMI were included. Blood samples were drawn before and immediately after percutaneous coronary intervention (PCI), at day 1, and after 4 months. Cardiac magnetic resonance imaging was performed in the acute phase and after 4 months. Clinical events were registered during 12 months' follow-up and all-cause mortality after median 70 months' follow-up.
RESULTS Patients with IL-8 levels greater than the median measured both immediately after PCI and at day 1 had larger final infarct size, lower LV ejection fraction, larger increase in LV end-diastolic volume, and higher frequency of microvascular obstruction. After multivariate adjustment, high IL-8 levels at day 1 were associated with an increased risk of developing a large MI and having reduced LV ejection fraction at 4 months, also after adjustment for peak troponin value. Patients with IL-8 levels in the highest quartile measured at all sampling points were more likely to have a clinical event during the first 12 months after the MI and had lower overall survival during long-term follow-up.
CONCLUSIONS High levels of circulating IL-8were associatedwith large infarct size, impaired recovery of LV function, and adverse clinical outcome in patients with STEMI, suggesting IL-8 as a future therapeutic target based on its important role in post-infarction inflammation.

• 出版日期2018-7-10