Antidepressant activity of carbamates and urea derivatives

作者：Perveen Shahnaz^*; Fatima Nasreen; Khan Muhammad Aitmaud; Dar Ahsana; Khan Khalid M; Afza Nighat; Voelter Wolfgang

来源：Medicinal Chemistry Research, 2012, 21(9): 2709-2715.

DOI：10.1007/s00044-011-9797-8

• Antidepressant
• Carbamates
• Urea derivatives
• Forced swim test
• Thiourea

Thirteen (13) compounds of N-phenyl-O-alkyl carbamates (1 and 3), N,N-diethyl-N%26apos;-alkyl/aryl/phenylpiperazinoureas (4-6, 8-12), N-phenyl-N%26apos;-phenylpiperazino/imidazoureas (2, 7), and N-ethyl-(N%26apos;-phenylpiperazino) thioureas 13 were synthesized and tested for their antidepressant-like activity in mice. It was found that compound N-phenyl-O-heptyl carbamate 1 and N-phenyl-N%26apos;-phenylpiperazinourea 2 showed 32.5 and 27.7% antidepressant activity in the forced swim test in mice, respectively. Considering other carbamates it was found that a decrease in alkyl chain length caused a marked decline in the antidepressant activity. Compounds 1-4 show even higher activities in the forced swim test than the standard phenelzine.

• 出版日期2012-9