New Driver for Lipid Synthesis

作者：Houten Sander M^*; Argmann Carmen A

来源：Cell, 2011, 147(4): 719-721.

DOI：10.1016/j.cell.2011.10.019

Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a classic feedback loop. Walker et al. (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity. These findings suggest a link between lipid synthesis and cellular pathways involved in methylation.

• 出版日期2011-11-11