Assessment of effective absorbed dose of In-111-DTPA-Buserelin in human on the basis of biodistribution rat data

作者：Lahooti Afsaneh; Shanehsazzadeh Saeed^*; Jalilian Amir Reza; Tavakoli Mohammad Bagher

来源：Radiation Protection Dosimetry, 2013, 154(1): 1-8.

DOI：10.1093/rpd/ncs137

In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of In-111-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of In-111-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats.

• 出版日期2013-4