Autoimmune Hemolytic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation: Analysis of 533 Adult Patients Who Underwent Transplantation at King's College Hospital

作者：Wang Meng^*; Wang Wenjia; Abeywardane Ayesha; Adikarama Malinthi; McLornan Donal; Raj Kavita; de Lavallade Hugues; Devereux Stephen; Mufti Ghulam J; Pagliuca Antonio; Potter Victoria T; Mijovic Aleksandar

来源：Biology of Blood and Marrow Transplantation, 2015, 21(1): 60-66.

DOI：10.1016/j.bbmt.2014.09.009

• Autoimmune hemolytic anemia
• Allogeneic hematopoietic stem cell transplantation
• Mortality

Autoimmune hemolytic anemia (AIHA) is a recognized complication of hematopoietic stem cell transplantation (HSCT); it is often refractory to treatment and carries a high mortality. To improve understanding of the incidence, risk factors, and clinical outcome of post-transplantation AIHA, we analyzed 533 patients who received allogeneic HSCT, and we identified 19 cases of AIHA after HSCT (overall incidence, 3.6%). The median time to onset, from HSCT to AIHA, was 202 days. AIHA was associated with HSCT from unrelated donors (hazard ratio [HR], 5.28; 95% confidence interval [CI], 1.22 to 22.9; P =.026). In the majority (14 of 19; 74%) of AIHA patients, multiple agents for treatment were required, with only 9 of 19 (47%) patients achieving complete resolution of AIHA. Patients with post-transplantation AIHA had a higher overall mortality (HR, 2.48; 95% CI, 1.33 to 4.63; P =.004), with 36% (4 of 11 cases) of deaths attributable to AIHA.

• 出版日期2015-1