Development of a microbial dose response visualization and modelling application for QMRA modelers and educators

作者：Weir Mark H; Mitchell Jade; Flynn William; Pope Joanna M

来源：Environmental Modelling & Software, 2017, 88: 74-83.

DOI：10.1016/j.envsoft.2016.11.011

• QMRA
• Microbial dose response
• Optimization
• Software
• Wiki

Microbial dose response modelling is vital to a well-characterized microbial risk estimate. Dose response modelling is an inherently multidisciplinary field, which collates knowledge and data from disparate scientific fields. This multidisciplinary nature presents a key challenge to the expansion of microbial dose response modelling into new groups of researchers and modelers. This research employs a dose response optimization R code used in 18 peer-reviewed research studies to develop a multi-functional dose response software. The underlying R code performs an optimization of the two primary dose response models using the MLE method and outputs statistical analyses of the fits and bootstrapped uncertainty information for the models. VizDR (Visual Dose Response) was developed to provide microbial dose response modelling capabilities to a larger audience. VizDR is programmed in JavaScript with underlying Python scripts for intercommunication with Rserve. VizDR allows for dose response model visualization and optimization of a user's own experimental data.

• 出版日期2017-2