A High-Potency, Multimechanism Skin Care Regimen Provides Significant Antiaging Effects: Results From a Double-Blind, Vehicle-Controlled Clinical Trial

作者：Farris Patricia K^*; Edison Brenda L; Brouda Irina; Weinkauf Ronni L; Green Barbara A

来源：Journal of Drugs in Dermatology, 2012, 11(12): 1447-1454.

Skin aging is a multifaceted biological process characterized by the appearance of wrinkles, pigmentation irregularities, and loss of firmness. These symptoms cannot be fully addressed by any single skin care ingredient or noninvasive cosmetic procedure. A comprehensive treatment approach, including the use of clinically proven topical skin care formulations, provides optimal antiaging effects. A high-strength skin care regimen (NeoStrata (R) Skin Active; NeoStrata Company, Inc, Princeton, NJ) was developed to deliver a combination of more than 35% active benefit ingredients, including the alpha-hydroxy acid glycolic acid, the polyhydroxy acid gluconolactone, maltobionic acid, N-acetylglucosamine, retinol, peptides, antioxidants, and apple stem cell extract. The products (cleanser, day cream, night cream, eye cream) were formulated to provide antiaging benefits across all skin layers via multiple mechanisms of action. The regimen was evaluated in a randomized, double-blind, vehicle-controlled clinical trial over 16 weeks, with a subset continuing to 30 weeks. Sixty-nine Caucasian women (active group, n=44; vehicle group, n=25) completed 16 weeks of twice-daily treatment. Results showed the active group improved significantly better than the vehicle group for: all clinician-graded aging symptoms beginning as early as 2 weeks; pinch recoil as a measure of firmness/elasticity; dermal density, which was measured using ultrasound; and total skin thickness, which was measured using digital calipers. Clinical photography revealed younger-looking skin. Seventeen subjects from the active group continued to receive the active regimen until week 30. Improvement in all parameters of aging was shown to be significantly greater at week 30 than at week 16, and dermal density continued to increase. The comprehensive benefits observed in this study over the cosmetic vehicles are believed to have been achieved through the synergistic actions of the benefit ingredients in the active regimen. J Drugs Dermatol. 2012;11(12):1447-1454.

• 出版日期2012-12