Spatial distribution of resting-state BOLD regional homogeneity as a predictor of brain glucose uptake: A study in healthy aging

作者：Bernier Michael^*; Croteau Etienne; Castellano Christian Alexandre; Cunnane Stephen C; Whittingstall Kevin

来源：NeuroImage, 2017, 150: 14-22.

DOI：10.1016/j.neuroimage.2017.01.055

• Glucose uptake (CMRGlu)
• BOLD amplitude (ALFF)
• BOLD synchrony (ReHo)
• Graph-theory
• Aging

Positron emission tomography using [18F]-fluorodeoxyglucose (PET-FDG) is the primary imaging modality used to measure glucose metabolism in the brain (CMRGlu). CMRGIu has been used as a biomarker of brain aging and neurodegenerative diseases, but the complexity and invasive nature of PET often limits its use in research. There is therefore great interest in developing non-invasive metrics for estimating brain CMRGlu. We therefore investigated resting state fMRI metrics such as regional homogeneity (ReHo), amplitude of low frequency fluctuations (ALFF) and regional global connectivity (Closeness) with multiple analytical approaches to determine their relationship to CMRGlu. We investigated this relation in two distinct cognitively healthy populations separated by age (27 young adults and 35 older adults). Overall, we found that both regionally and across participants, ReHo strongly correlated with CMRGIu in healthy young and older adults. Moreover, ReHo demonstrated the same age-related differences as CMRGlu throughout all cortical regions, particularly in the default network and frontal areas.

• 出版日期2017-4-15