Diastereoselective Coupling of Chiral Acetonide Trisubstituted Radicals with Alkenes

作者:Tao Daniel J; Muuronen Mikko; Slutskyy Yuriy; Le Alexander; Furche Filipp*; Overman Larry E*
来源:Chemistry - A European Journal, 2016, 22(26): 8786-8790.
DOI:10.1002/chem.201601957

摘要

The stereochemical outcome of reactions of chiral nucleophilic trisubstituted acetonide radicals with electron-deficient alkenes is dictated by a delicate balance between destabilizing non-bonding interactions and stabilizing hydrogen-bonding between substituents on the alpha and beta carbons.

  • 出版日期2016-6-20