New sugar-derived bifunctional chiral ureas as highly effective organocatalysts in asymmetric aza-Henry reaction

作者：Robak Jolanta; Kryczka Boguslaw; Swierczynska Barbara; Zawisza Anna; Porwanski Stanislaw^*

来源：Carbohydrate Research, 2015, 404: 83-86.

DOI：10.1016/j.carres.2014.11.019

• Aza-Henry
• Saccharides
• Urea
• Organocatalyst

A simple synthesis of series of new catalysts derived from chiral bifunctional ureas is described. The aza-Henry reaction of imines with nitromethane was promoted by sugar derived bifunctional organocatalysts to give optically active beta-nitroamines. The aza-Henry reaction products were obtained in good yields (35-98%) and ee up to 99%.

• 出版日期2015-3-2