A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1

作者：Battilocchio Claudio; Deadman Benjamin J; Nikbin Nikzad; Kitching Matthew O; Baxendale Ian R; Ley Steven V^*

来源：Chemistry - A European Journal, 2013, 19(24): 7917-7930.

DOI：10.1002/chem.201300696

• batch processes
• flow chemistry
• medicinal chemistry
• organic chemistry
• synthetic methods

Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor-1 antagonist, with its machine-assisted flow chemistry alternative. By using these enabling tools, combined with solid-supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.

• 出版日期2013-6