Autophagy regulation in macrophages and neutrophils

作者：Mihalache Cristina C; Simon Hans Uwe^*

来源：Experimental Cell Research, 2012, 318(11): 1187-1192.

DOI：10.1016/j.yexcr.2011.12.021

• Apoptosis
• Autophagy
• Cell death
• Innate immunity
• Macrophages
• Necrosis
• Neutrophils
• Reactive oxygen species

Autophagy is a conserved proteolytic mechanism that degrades cytoplasmic material including cell organelles. Accumulating evidence exists that autophagy also plays a major role in immunity and inflammation. Specifically, it appears that autophagy protects against infections and inflammation. Here, we review recent work performed in macrophages and neutrophils, which both represent critical phagocytes in mammalians.

• 出版日期2012-7-1