A gadolinium(III)-coumarin complex based MRI/Fluorescence bimodal probe for the detection of fluoride ion in aqueous. medium

作者：Wang, Yue; Wang, Xueyi; Meng, Qingtao^*; Jia, Hongmin; Zhang, Run; Zhu, Peixun; Song, Renfeng; Feng, Huan; Zhang, Zhiqiang^*

来源：Tetrahedron, 2017, 73(38): 5700-5705.

DOI：10.1016/j.tet.2017.08.007

• MRI/Fluorescence
• Bimodal
• Probe
• Fluoride ion
• Detection

By virtue of high affinity of Gadolinium(III) with fluoride, a novel MRI/fluorescence bimodal probe was prepared by self-assembly of Gd(III) based contrast agent with the coumarin-based fluorophore (CL). Upon addition of fluoride ion (F-) to the aqueous solution of EDTA-Gd(III)-CL, the replacement of coordination CL occurs, realizing switch-on both the longitudinal relaxivity (r(1)) and fluorescence responses, simultaneously. The fluorescence detection limit for fluoride ions was established at 0.15 mu M. EDTA-Gd(III)-CL features of favorable selectivity towards F- for both relaxivity and fluorescence, reliability at physiological pH allow its potential application in biomedical diagnosis fields.

• 出版日期2017-9-21
• 单位辽宁科技大学