Application of tetrahydrothiazole-2-thione (TTT) in the reaction of selective side chain protection of lysine

作者：Xing Ming Gao; Yun Hua Ye^*

来源：Acta Chimica Sinica, 2007, 65(16): 1654-1656.

• tetrahydrothiazole-2-thione (TTT)
• lysine derivative
• amino acid-cupric complex

A lysine derivative with selectively protected side chain N-alpha-Boc-N-epsilon-Fmoc-L-Lys-OH was synthesized through decomposition of lysine cupric complex with tetrahydrothiazole-2-thione (TTT). The results indicate that the decomposition is faster and more complete, the by-product was easier to be removed than that with traditional reagents (H2S, EDTA, HCl).

• 出版日期2007-8-28
• 单位北京大学