科研之友
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摘要
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by extracellular amyloid-beta (A beta) and intraneuronal tau protein brain pathologies. The most significant risk factor for non-familial AD is the presence of the E4 isoform of the cholesterol transporter apolipoprotein E (apoE). Despite extensive basic research, the exact role of apoE in disease aetiology remains unclear. Correspondingly, therapeutic targeting of apoE in AD is at an early preclinical stage. In this review, I discuss the key interactions of apoE and A beta pathology, the current progress of preclinical animal models and the caveats of existing therapeutic approaches targeting apoE. Finally, novel Alzheimer's genetics and A beta-independent disease mechanisms are highlighted.
- 出版日期2012
