Genetic Structure of the Spanish Population

作者：Gayan Javier; Galan Jose J; Gonzalez Perez Antonio; Eugenia Saez Maria; Teresa Martinez Larrad Maria; Zabena Carina; Carmen Rivero M; Salinas Ana; Ramirez Lorca Reposo; Moron Francisco J; Luis Royo Jose; Moreno Rey Concha; Velasco Juan; Carrasco Jose M; Molero Eva; Ochoa Carolina; Dolores Ochoa Maria; Gutierrez Marta; Reina Mercedes; Pascual Rocio; Romo Astorga Alejandro; Luis Susillo Gonzalez Juan; Vazquez Enrique; Real Luis M; Ruiz Agustin^*; Serrano Rios Manuel

来源：BMC Genomics, 2010, 11: 326.

DOI：10.1186/1471-2164-11-326

Background: Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias.
Results: In this study we have sampled over 800 unrelated individuals from the population of Spain, and have genotyped them with a genome-wide coverage. We have carried out linkage disequilibrium, haplotype, population structure and copy-number variation (CNV) analyses, and have compared these estimates of the Spanish population with existing data from similar efforts.
Conclusions: In general, the Spanish population is similar to the Western and Northern Europeans, but has a more diverse haplotypic structure. Moreover, the Spanish population is also largely homogeneous within itself, although patterns of micro-structure may be able to predict locations of origin from distant regions. Finally, we also present the first characterization of a CNV map of the Spanish population. These results and original data are made available to the scientific community.

• 出版日期2010-5-25