Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder

作者：Ruocco Anthony C^*; Medaglia John D; Tinker Jennifer R; Ayaz Hasan; Forman Evan M; Newman Cory F; Williams J Michael; Hillary Frank G; Platek Steven M; Onaral Banu; Chute Douglas L

来源：Psychiatry Research: Neuroimaging , 2010, 181(3): 233-236.

DOI：10.1016/j.pscychresns.2009.12.001

• Borderline personality disorder
• Functional near infrared spectroscopy
• Prefrontal cortex

Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n = 10) and matched non-psychiatric comparison subjects (n = 10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.

• 出版日期2010-3-30