An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

作者：Ullah Nisar^*; Haladu Shamsuddeen A; Mosa Basem A

来源：Tetrahedron Letters, 2011, 52(2): 212-214.

DOI：10.1016/j.tetlet.2010.10.164

• Spermatinamine
• Icmt inhibitor
• Anticancer drug
• Azlactone formation

An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%.

• 出版日期2011-1-12
• 单位中国石油大学（北京）