alpha,beta-Dehydrogenation of esters with free O-H and N-H functionalities via allyl-palladium catalysis

作者：Szewczyk Suzanne M; Zhao Yizhou; Sakai Holt A; Dube Pascal; Newhouse Timothy R^*

来源：Tetrahedron, 2018, 74(26): 3293-3300.

DOI：10.1016/j.tet.2018.02.028

• Allyl-palladium
• Dehydrogenation
• Esters
• beta-Amino esters

A direct and selective method for the alpha,beta-dehydrogenation of esters using palladium catalysis in the presence of free O-H and N-H functionalities is reported herein. Allyl-palladium catalysis allows for preservation of readily oxidizable functionalities such as amines and alcohols. Furthermore, an economical protocol using LDA was developed for the dehydrogenation of beta-amino esters.

• 出版日期2018-6-28