A spatial covariance I-123-5IA-85380 SPECT study of alpha 4 beta 2 nicotinic receptors in Alzheimer's disease

作者：Colloby Sean J^*; Field Robert H; Wyper David J; O'Brien John T; Taylor John Paul

来源：Neurobiology of Aging, 2016, 47: 83-90.

DOI：10.1016/j.neurobiolaging.2016.07.017

• Alzheimer's disease
• Cholinergic
• Acetylcholine
• Nicotinic
• Spatial covariance
• SPECT

Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these deficits and relationship with known brain networks is unknown. In this study, we sought to clarify this and used I-123-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine ((123)5IA-85380) single photon emission computed tomography to investigate spatial covariance of alpha 4 beta 2 nicotinic acetylcholine receptors in AD and healthy controls. Thirteen AD and 16 controls underwent 1235IA-85380 and regional cerebral blood flow ((99)mTc-exametazime) single photon emission computed tomography scanning. We applied voxel principal component (PC) analysis, generating series of principal component images representing common intercorrelated voxels across subjects. Linear regression generated specific alpha 4 beta 2 and regional cerebral blood flow covariance patterns that differentiated AD from controls. The alpha 4 beta 2 pattern showed relative decreased uptake in numerous brain regions implicating several networks including default mode, salience, and Papez hubs. Thus, as well as basal forebrain and brainstem cholinergic system dysfunction, cholinergic deficits mediated through nicotinic acetylcholine receptors could be evident within key networks in AD. These findings may be important for the pathophysiology of AD and its associated cognitive and behavioral phenotypes.

• 出版日期2016-11