Antimicrobial toxicity studies of ionic liquids leading to a %26apos;hit%26apos; MRSA selective antibacterial imidazolium salt

作者：Coleman Deborah^*; Spulak Marcel; Teresa Garcia M; Gathergood Nicholas

来源：Green Chemistry, 2012, 14(5): 1350-1356.

DOI：10.1039/c2gc16090k

Imidazolium salts can be classed as surfactants, detergents, ionic liquids, reagents, catalysts or solvents. A study of the toxicity and ecotoxicity of these salts yields valuable information for their use as pharmaceuticals as well as impact on the environment. Our approach to screen a series of chiral imidazolium salts for toxicity to bacteria and fungi, including clinical pathogen strains, has led to the identification of a %26apos;hit%26apos; MRSA selective antimicrobial compound. Preliminary structure-activity-relationship (SAR) information (required position of L-phenylalanine and L-valine group) is also elucidated within this first generation of compounds. Conversely, most of the imidazolium salts were nontoxic (IC95 %26gt; 2 mM) to the 12 fungi strains and 8 bacteria strains screened, and we propose that they are suitable candidates for %26apos;green chemistry%26apos; applications. Ecotoxicity studies (Biodegradation ISO 14593 %26apos;CO2 Headspace Test%26apos;) of two bromide ionic liquids containing L-phenylalanine residues indicate that these ionic liquids passed the test (%26gt;60% in 28 days) and classed as readily biodegradable.

• 出版日期2012