Alisporivir Has Limited Antiviral Effects Against Ebola Virus Strains Makona and Mayinga

作者：Chiramel Abhilash I^*; Banadyga Logan; Dougherty Jonathan D; Falzarano Darryl; Martellaro Cynthia; Brees Dominique; Taylor R Travis; Ebihara Hideki; Best Sonja M

来源：Journal of Infectious Diseases, 2016, 214(suppl 3): S355-S359.

DOI：10.1093/infdis/jiw241

• alisporivir
• Ebola virus
• cyclophilin A
• antivirals
• flavivirus

Antiviral therapeutics with existing clinical safety profiles would be highly desirable in an outbreak situation, such as the 2013-2016 emergence of Ebola virus (EBOV) in West Africa. Although, the World Health Organization declared the end of the outbreak early 2016, sporadic cases of EBOV infection have since been reported. Alisporivir is the most clinically advanced broad-spectrum antiviral that functions by targeting a host protein, cyclophilin A (CypA). A modest antiviral effect of alisporivir against contemporary (Makona) but not historical (Mayinga) EBOV strains was observed in tissue culture. However, this effect was not comparable to observations for an alisporivir-susceptible virus, the flavivirus tick-borne encephalitis virus. Thus, EBOV does not depend on (CypA) for replication, in contrast to many other viruses pathogenic to humans.

• 出版日期2016-10-15
• 单位NIH; Saskatchewan; Saskatoon