Anti-inflammatory activity of licochalcone a isolated from Glycyrrhiza inflata

作者：Cui, Yongming; Ao, Mingzhang; Li, Wei; Hu, Jing; Yu, Longjiang^*

来源：Zeitschrift fur Naturforschung Section C-A Journal of Biosciences, 2008, 63(5-6): 361-365.

• licochalcone A
• Glycyrrhiza inflata
• anti-inflammatory activity

Licochalcone A was isolated from the roots of Glycyrrhiza inflata and evaluated for its anti-inflammatory activity in xylene-induced mice ear edema and carrageenan-induced paw edema tests. At the same time, the inhibition of prostaglandin biosynthesis by licochalcone A was also studied in lipopolysaccharide (LPS)-induced mouse macrophage cells. At 5 mg/ear, licochalcone A showed remarkable effects against acute inflammation induced by xylene, and at the doses of 2.5, 5, 10 mg/kg (p.o.), licochalcone A reduced significantly paw edema induced by carrageenan compared to the control at the fourth hour. Both COX-2 activity and expression were significantly inhibited by licochalcone A at all the test doses. Therefore, licochalcone A could be a useful compound for the development of new anti-inflammatory agents.

• 出版日期2008-5
• 单位华中科技大学