Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding

作者：Samiappan Manickasundaram; Alasibi Samaa; Cohen Luria Rivka; Shanzer Abraham; Ashkenasy Gonen^*

来源：Chemical Communications, 2012, 48(77): 9577-9579.

DOI：10.1039/c2cc35166h

Peptide sequences modified with lanthanide-chelating groups at their N-termini, or at their lysine side chains, were synthesized, and new Ln(III) complexes were characterized. We show that partial folding of the conjugates to form trimer coiled coil structures induces coordination of lanthanides to the ligand, which in turn further stabilizes the 3D structure.

• 出版日期2012