Application of Click Chemistry in Biomedical Polymers

作者：Yang Qizhi; Liu Jia; Jiang Xulin^*

来源：Progress in Chemistry, 2010, 22(12): 2377-2387.

• click chemistry
• non-viral gene vector
• polymeric micelles
• hydrogel
• drug delivery

Click chemistry has attracted great attentions since its concept was introduced in less than a decade, because the click chemistry reaction can be carried out under mild and simple reaction conditions, resulting in high reaction efficiency with easy post-treatment for the obtained products. In this review, the synthesis of biomedical polymers using click reaction technique is briefly introduced. The progress on preparation via copper-catalyzed azide-alkyne cycloaddition click reaction and application of the multifunctional and intelligent polymers for non-viral polymeric gene carriers, polymeric-micelles for drug delivery and polymer-based hydrogel is summarized. The limitations and prospective applications of the click chemistry technique for synthesis of biomedical polymers are also discussed.

• 出版日期2010-12
• 单位武汉大学