Diagnostic ability of ganglion cell complex thickness to detect glaucoma in high myopia eyes by Fourier domain optical coherence tomography

作者：Wang, Wei-Wei; Wang, Huai-Zhou^*; Liu, Jian-Rong; Zhang, Xi-Fang; Li, Meng; Huo, Yan-Jiao; Yang, Xin-Guang

来源：International Journal of Ophthalmology, 2018, 11(5): 791-796.

DOI：10.18240/ijo.2018.05.12

• optical coherence tomography
• glaucoma
• high myopia
• ganglion cell complex

AIM: To evaluate the ability of macular ganglion cell complex (GCC) thickness using Fourier domain optical coherence tomography (FD-OCT) to detect glaucoma in highly myopic eyes. @@@ METHODS: Cross-sectional study. A total of 114 participants, consecutively were enrolled. Macular GCC thickness and peripapillary retinal nerve fiber layer (RNFL) thickness were obtained with RTVue FD-OCT. Receiver operating characteristics curves were constructed for each measurement parameter, and areas under the curves (AUCs) were compared. @@@ RESULTS: Both the average GCC and average RNFL thickness showed negative correlations with axial length (rGCC=-0.404, P= 0.001; rRNFL=-0.561, P< 0.001). The largest AUCs from GCC, and RNFL parameters were 0.968 [global loss volume (GLV)], and 0.855 (average RNFL), respectively. GLV was significantly better for detecting high myopic glaucoma than average RNFL (P< 0.001). @@@ CONCLUSION: Macular GCC thickness has higher diagnostic power than peripapillary RNFL thickness to discriminate glaucoma patients from non-glaucoma subjects in high myopia.

• 出版日期2018-5-18
• 单位首都医科大学; 西安交通大学