Anti-tumor activity and related mechanism study of Bacillus Polymyxa transformed Panax ginseng C. A. Mey

作者：Gao, Yugang; Liu, Jingting; Ji, Qing; Zhao, Yan; Zang, Pu^*; He, Zhongmei; Zhu, Hongyan; Zhang, Lianxue

来源：Process Biochemistry, 2018, 72: 198-208.

DOI：10.1016/j.procbio.2018.06.013

• Bacillus polymyxa
• Ginseng
• Anti-tumor effect

Panax ginseng C. A. Mey has a history of drug use for thousands of years, and ginsenoside is the main active ingredient. Whether the conversion products of ginseng by Bacillus polymyxa can enhance the anti-tumor activity is to be further studied. This paper aims to study the anti-tumor activity of transformed ginsenoside products by Bacillus polymyxa in vivo and vitro, the results were as follows: In vitro, apoptosis mainly occurred in the late stage for breast cancer cells MCF-7, and the conversion products had better anti-tumor effect than ginseng group (P < 0.05). In vivo, Compared with the model group, the low, medium and high dose group could inhibit the growth of H22 tumor, improve the organ index of mice, promote the H22 tumor apoptosis (P < 0.05), increase the proliferation activity of lymphocyte cells and CD4(+) /CD8(+) ratio, improve the contents of IgG, IgM, IgE, IFN-gamma, IL-2, IL-6, IL-12, decrease TGF-beta that can inhibit IL-2 in serum. The conversion products could enhance cell immunity, organ immunity, humoral immunity and anti-tumor effect. In particular, TNF-alpha activity was increased while TGF-beta was reduced. Positive drug 5-FU had the effects of improving cell and organ immunity, but also had certain side effects.

• 出版日期2018-9
• 单位吉林农业大学