Association behavior of one-end hydrophobically modified poly[N-5-(2-hydroxyethyl) L-glutamine] in water/ethylene glycol mixed solvent

作者：Inomata Katsuhiro^*; Doi Reina; Yamada Erina; Sugimoto Hideki; Nakanishi Eiji

来源：Colloid and Polymer Science, 2007, 285(10): 1129-1137.

DOI：10.1007/s00396-007-1665-1

• poly[N-5-(2-hydroxyethyl) L-glutamine]
• micelle
• association behavior
• amphiphilic polymers
• light scattering

Amphiphilic polymers Cn-PHEG consisting of water-soluble poly[N5-2-(hydroxyethyl) L-glutamine] (PHEG) and hydrophobic alkyl chain (carbon number n=12, 14, 16, or 18) attached at the PHEG terminal was prepared, and association behavior and structure of associate for Cn-PHEG in selective solvent (water/ethylene glycol mixed solvent) have been investigated. alpha-Helix content of PHEG block for all the polymers increased with weight fraction of ethylene glycol in the mixed solvent (W-EG). By light scattering measurements, formation of a small micelle was suggested for C14-, C16-, and C18-PHEG when W-EG=0. With the increase in W-EG, appearance of a larger associate was revealed for C16- and C18-PHEG. Evaluated molecular weight and radius of gyration suggested that the micelle is star-like sphere when W-EG=0 and worm-like cylinder when W-EG=0.7. C12-PHEG did not demonstrate any distinct micellization behavior because of the weak hydrophobicity of C12 chain.

• 出版日期2007-7