A fatal case of oleandrin poisoning

作者：Wasfi Ibrahim A^*; Zorob Omar; Al Katheeri Nawal A; Al Awadhi Anwar M

来源：Forensic Science International, 2008, 179(2-3): E31-E36.

DOI：10.1016/j.forsciint.2008.05.002

• Oleandrin
• LC-MS/MS

The study presents a case of fatal poisoning with oleander leaves in an adult diabetic male. After repeated vomiting, and gastrointestinal distress the patient was admitted at the hospital with cardiac symptoms 1 h after the ingestion. Urine samples were assayed immunochemically and by GC-MS for drugs of abuse and for general toxicological screen. Blood was analyzed for alcohol and volatiles by static head space GC-MS. Blood and oleander leaves were analyzed by LC-MS/MS for oleandrin and related compounds, the main cardiac glycosides of Nerium oleander. Oleandrin was detected by LC-MS/MS in the blood sample at a concentration of similar to 10 ng/ml. Another cardiac glycoside with pseudo-molecular ion of m/z 577, a likely structural isomer of oleandrin, was also detected in the blood and oleander leaves. However, by using the response as a function of concentration for oleandrin, this cardiac glycoside was roughly estimated at a concentration of similar to 10 ng/ml in the deceased blood. This would give a total fatal blood concentration of cardiac glycosides of about similar to 20 ng/ml in the deceased blood.

• 出版日期2008-8-6