Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp SK2YWS-L

作者：Tan, Chunbin; Liu, Zhaoming; Chen, Senhua; Huang, Xishan; Cui, Hui; Long, Yuhua; Lu, Yongjun^*; She, Zhigang^*

来源：Scientific Reports, 2016, 6(1): 36609.

DOI：10.1038/srep36609

• MARINE NATURAL-PRODUCTS
• PESTALOTIOPSIS-MICROSPORA
• ASPERGILLUS-TERREUS
• METABOLITES
• SESTERTERPENOIDS
• INHIBITOR
• SPONGE
• WENTII

Three novel 2,3-diaryl indone derivatives, ascomindones A-C (1-3), and two new isobenzofuran derivatives, ascomfurans A (4) and B (5), together with four know compounds (6-9) were isolated from the culture of a mangrove-derived fungus Ascomycota sp. SK2YWS-L. Their structures were elucidated on the interpretation of spectroscopic data. 1 and 4 were further constructed by analysis of X-ray diffraction. Antioxidant properties based on 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical scavenging activities and the ferric reducing ability power (FRAP) of the new compounds were assayed. All of them exhibited significant effects, of which 1 showed more potent activity than ascorbic acid in scavenging DPPH radical with IC50 value of 18.1 mu M.

• 出版日期2016-11-4
• 单位中山大学