NOVEL SYNTHESIS OF CARBOCYCLIC OXETANOCIN ANALOGS (2-ALKOXY-C.OXT-A) AND THEIR TUBE FORMATION ACTIVITIES OF HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC)

作者：Sakakibara Norikazu; Tsukamoto Ikuko; Tsuruta Takashi; Takata Maki; Konishi Ryoji; Maruyama Tokumi^*

来源：Heterocycles, 2012, 85(5): 1105-1116.

DOI：10.3987/COM-12-12441

• 2-Alkoxy-C.OXT-A Analog
• 2-CI-C.OXT-A
• Nucleoside Derivative
• Tube Formation Activity
• HUVEC

We succeeded in the effective synthesis of five types of 2-alkoxy-C.OXT-A analogs (9, 10a-d) by applying the de novo synthesis of 2-alkoxyadenosine derivatives (2), which was developed in our laboratory. For these synthesized compounds, the angiogenic activity was evaluated using human umbilical vein endothelial cells. Four products (10a-d) enhanced the activity of the cell; in particular, 2-methoxy-C.OXT-A (10a) and 2-isopropoxy-C.OXT-A (10c) at a concentration of 100 mu M exhibited the same or stronger potency than the vascular endothelial cell growth factor.

• 出版日期2012-5-1