Preparation and characterization of solid lipid nanoparticles loaded traditional Chinese medicine

作者：Li YC^*; Dong L; Jia A; Chang XM; Xue H

来源：International Journal of Biological Macromolecules, 2006, 38(3-5): 296-299.

DOI：10.1016/j.ijbiomac.2006.03.006

• tetrandrine
• solid lipid nanoparticles
• ultrasonication
• entrapment efficiency
• traditional Chinese medicine

Ultrasonication was employed to prepare solid lipid nanoparticles (SLN). The model traditional Chinese medicine, tetrandrine (TET), was incorporated into SLN. The TET-loaded SLN (TET-SLN) were spherical in the photograph of transmission electron microscope (TEM). The particle size measured by laser diffraction (LD) was found to be 157.3 +/- 8.2 nm. Zeta potential analyzer suggested the zeta potential of TET-SLN was -29.36 +/- 3.68 mV in distilled water. The entrapment efficiency (EE%) was determined with the sephadex gel chromatogram and high-performance liquid chromatogram, (HPLC), and up to 90.59% of TET was incorporated. Stability evaluation showed relatively long-term stability with only slight particle growth (P > 0.05) after storage at room temperature for 4 weeks. Therefore, ultrasonication is demonstrated to be a simple, available and effective method to prepare high quality SLN loaded traditional Chinese medicine.

• 出版日期2006-5-30
• 单位西安交通大学